Recombinant Human PCTK3 (CDK18)/CyclinY (N-GST tag) | Z500276

abm | Recombinant Human PCTK3 (CDK18)/CyclinY (N-GST tag) | Z500276

PCTK3 or PCTAIRE protein kinase 3 is a member of the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK3 is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2 . PCTK3 is expressed in a variety of human cell lines and tissues . Elevation in the protein levels of PCTAIRE 3 in the temporal cortex of Alzheimer's disease relative to control brains, have been observed. It is proposed that PCTAIRE 3 is a paired helical filaments-associated kinase that modulates tau phosphorylation.

Functions:

The specific activity of PCTK3 (CDK18)/CyclinY was determined to be 46 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PCTK3: PCTAIRE, PCTAIRE3 CyclinY: CCNY; C10orf9; CBCP1; CCNX; CFP1

Gene Symbol:

PCTK3/Cyclin Y

Gene ID:

N/A

Accession:

BC011526, NM_145012

Formulation:

50mM Tris-HCl, , pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

76

Molecular Weight 2 (kDA):

64

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.