Recombinant Human PFTK1 (CDK14)/CyclinY (N-GST tag) | Z500285

abm | Recombinant Human PFTK1 (CDK14)/CyclinY (N-GST tag) | Z500285

PFTK1 is a member of the CDC2 - related protein kinase family which is expressed primarily in the postnatal and adult nervous system . PFTK1 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. PFTK1 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to PFTK1 binding . PFTK1 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma.

Functions:

The specific activity of PFTK1 (CDK14)/CyclinY was determined to be 2.5 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PFTK1: CDK14; PFTAIRE1 Cyclin Y: CCNY; C10orf9; CBCP1; CCNX; CFP1

Gene Symbol:

PFTK1 (CDK14)/Cyclin

Gene ID:

N/A

Accession:

NM_012395 , NM_145012

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

72

Molecular Weight 2 (kDA):

64

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.