Recombinant Human PI3K (p110 alpha/p55 gamma) (N-His tag) | Z500288

abm | Recombinant Human PI3K (p110 alpha/p55 gamma) (N-His tag) | Z500288

PI3K (p110alpha/p55gamma) or Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position which serve as second messengers in growth signaling pathways. PI3K comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in the PI3K has been associated with insulin resistance and plays an important role in glucose homeostasis in vivo . PI3K also plays an essential role in the development and induction of mast cells in normal and pathogenic immune responses .

Functions:

The specific activity of PI3K(p110a/p55?)wasdetermined to be 14 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

p110a: PI3K, p110-alpha p55g: PIK3R3, p55, p55-GAMMA, FLJ41892

Gene Symbol:

PI3K (p110a/p55?)

Gene ID:

N/A

Accession:

NM_006218, BC021622

Formulation:

50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

111

Molecular Weight 2 (kDA):

61

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.