Recombinant Human PI3K (p110 beta/p85 alpha) (N-His tag) | Z500290

abm | Recombinant Human PI3K (p110 beta/p85 alpha) (N-His tag) | Z500290

The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110ß catalytic subunit (PIK3CB) plays a role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation . In animal model of prostate tumor formation induced by the tumor suppressor PTEN loss, ablation of p110ß impedes tumorigenesis with a concomitant diminution of AKT phosphorylation .

Functions:

The specific activity of PI3K (p110ß/p85a) was determined to be 15 nmol/min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

p110α: PIK3CB, PI3K, PIK3C1, PI3Kbeta, MGC133043, p110-BETA, DKFZp779K1237 p85α: PIK3R1, GRB1, p85-ALPHA

Gene Symbol:

PI3K (p110ß/p85a)

Gene ID:

N/A

Accession:

NM_006219, NM_181523

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

111

Molecular Weight 2 (kDA):

90

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.