Recombinant Human PI3K (p110 beta/p85 beta) (N-His tag) | Z500291

abm | Recombinant Human PI3K (p110 beta/p85 beta) (N-His tag) | Z500291

PI3K phosphorylate the 3-prime OH position of the inositol ring of inositol lipids which functions in signaling pathways that regulate cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kDa catalytic subunit and a 85-kDa adaptor subunit . PI3K plays a critical role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation. PI3K sustains alpha-2B-beta-3 integrin activation and stabilized platelet aggregation by regulating both integrin-dependent calcium flux and Gi activation of RAP1B .

Functions:

The specific activity of PI3K was determined to be 28 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

p110β: PI3K, PIK3C1, PI3Kbeta, MGC133043, p110-BETA, DKFZp779K1237 p85β: PIK3R2, P85B, p85-BETA

Gene Symbol:

PI3K (p110 beta/p85

Gene ID:

N/A

Accession:

NM_006219, NM_005027

Formulation:

50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

111

Molecular Weight 2 (kDA):

88

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.