Recombinant Human PI3K (p110 delta/p85 alpha) (N-His tag) | Z500292

abm | Recombinant Human PI3K (p110 delta/p85 alpha) (N-His tag) | Z500292

PI3K (p110d/p85a) is a member of the PI3K family that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring . PI3K (p110d/p85a) plays a role in oncogenic transformation, and is consistently expressed at a high level in blast cells from AML. PI3K (p110d/p85a) can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that lead to neutrophil polarization, and regulates directional migration, but not random locomotion . PI3K (p110d/p85a) signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.

Functions:

The specific activity of PI3K (p110d/p85a) was determined to be 50 nmol/min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

p110δ: p110δp85α: PIK3R1, GRB1, p85-ALPHA

Gene Symbol:

PI3K (p110d/p85a)

Gene ID:

N/A

Accession:

NM_005026, NM_181523

Formulation:

50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

111

Molecular Weight 2 (kDA):

86

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.