Recombinant Human PI4K2A (N-GST tag) | Z500294

abm | Recombinant Human PI4K2A (N-GST tag) | Z500294

PI4K2A or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes . PI4K2A is also required for Wnt to regulate LRP6 phosphorylation .

Functions:

The specific activity of PI4K2A was determined to be 95 nmol/min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

DKFZp761G1923; PI4KII; PIK42A; RP11-548K23.6

Gene Symbol:

PI4K2A

Gene ID:

N/A

Accession:

NM_018425

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

79

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.