Recombinant Human PI4KB (N-GST tag) | Z500296

abm | Recombinant Human PI4KB (N-GST tag) | Z500296

PI4KB is a member of the phosphatidylinositol 4-kinase family (PI4K) and is the first committed step in the production of the second messenger inositol-1,4,5-trisphosphate (PIP3). PI4KB regulates the golgi disintegration/reorganization during mitosis possibly via the phosphorylation of phosphatidylinositol . PI4KB is a type III enzyme that is sensitive to wortmannin and is responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. PI4KB is critical for glucose-induced insulin secretion due to its capacity to regulate the release of secretory granules . PI4KB inhibits the insulin-stimulated translocation of glucose transporter-4 in mouse adipocytes through its interaction with neuronal calcium sensor-1.

Functions:

The specific activity of PI4KB was determined to be 37 nmol/min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PI4K-BETA, pi4K92, PI4Kbeta, PI4KIIIbeta

Gene Symbol:

PI4KB

Gene ID:

N/A

Accession:

BC000029

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

120

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.