Recombinant Human PIP5K1A (N-GST tag) | Z500304

abm | Recombinant Human PIP5K1A (N-GST tag) | Z500304

PIP5K1A or phosphatidylinositol-4-phosphate 5-kinase 1 alpha phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1 is required for Wnt3a-induced LRP6 phosphorylation at ser1490 in mammalian cells . Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates through 'frizzled' and 'dishevelled', the latter of which directly interacts with and activated PIP5KI. PIP5K1A-mediated PIP production is crucial for HIV-1 entry and the early steps of infection in permissive lymphocytes . Overexpression of wild-type PI4P5K1A increases HIV-1 Env-mediated PIP production and enhances viral replication in primary lymphocytes.

Functions:

The specific activity of PIP5K1A was determined to be 1310 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

RP11-68I18.9

Gene Symbol:

PIP5K1A

Gene ID:

N/A

Accession:

BC007833

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

86

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.