Recombinant Human PIP5K1C (N-GST tag) | Z500306

abm | Recombinant Human PIP5K1C (N-GST tag) | Z500306

PIP5K1C or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with ß-catenin and increases ß-catenin activity downstream of growth factor stimulation . PIP5K1C expression and kinase activity enhance ß-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitating RhoA GTPase and integrin activation by chemoattractants .

Functions:

The specific activity of PIP5K1C was determined to be 220 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

KIAA0589; LCCS3; PIP5K-GAMMA; PIP5Kgamma; PIPKIg_v4

Gene Symbol:

PIP5K1C

Gene ID:

N/A

Accession:

NM_012398

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

120

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.