Recombinant Human PKC iota (N-GST tag) | Z500317

abm | Recombinant Human PKC iota (N-GST tag) | Z500317

PKC? is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKC? showed greatest homology to PKCzeta, with 72% identity overall rising to 84% in the catalytic domain. Protein kinase C iota (PKC?) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKC? in the colon are highly susceptible to carcinogen-induced colon carcinogenesis .

Functions:

The specific activity of PKC?was determined to be 664 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PRKCI; DXS1179E; MGC26534; nPKC-iota

Gene Symbol:

PKC?

Gene ID:

N/A

Accession:

NM_002740

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

98

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.