Recombinant Human PKC theta (N-GST tag) | Z500320

abm | Recombinant Human PKC theta (N-GST tag) | Z500320

Protein Kinase C, theta (PKC?) is important component in the intracellular signaling cascade . Recent studies have suggested that local accumulation of fat metabolites inside skeletal muscle may activate a serine kinase cascade involving PKC-theta leading to defects in insulin signaling and glucose transport in skeletal muscle . Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. PKC-theta is a crucial component mediating fat-induced insulin resistance in skeletal muscle and is a potential therapeutic target for the treatment of type 2 diabetes .

Functions:

The specific activity of PKC?was determined to be 910 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PRKCQ, PRKCT, MGC126514, MGC141919, nPKC-theta

Gene Symbol:

PKC?

Gene ID:

N/A

Accession:

NM_006257

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

110

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.