Recombinant Human PKN2/PRK2 (N-GST tag) | Z500324

abm | Recombinant Human PKN2/PRK2 (N-GST tag) | Z500324

PKN2 (also known as PRK2) is a Rho effector and a member of the protein kinase C superfamily of serine/threonine kinases. PKN2 is an essential regulator of both entry into mitosis and exit from cytokinesis in HeLa S3 cells . PKN2 is required for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of Cdc25B, the phosphatase required for activation of mitotic cyclin/Cdk1 complexes at the G2/M transition. C-terminus of PKN2 could be a potential drug target for effector-specific pharmacological intervention of Rho-medicated biological processes .

Functions:

The specific activity of PKN2/PRK2 was determined to be 74 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PRKCL2, PKN2, PRK2, PAK2, Pak-2, PRO2042, MGC71074, MGC150606

Gene Symbol:

PKN2/PRK2

Gene ID:

N/A

Accession:

NM_006256

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

145

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.