Recombinant Human PLK4 (N-GST tag) | Z500329

abm | Recombinant Human PLK4 (N-GST tag) | Z500329

PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells .The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development .

Functions:

The specific activity of PLK4 was determined to be 5.6 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

SAK, STK18

Gene Symbol:

PLK4

Gene ID:

N/A

Accession:

NM_014264

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

140

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.