Recombinant Human SIK (N-GST tag) | Z500358

abm | Recombinant Human SIK (N-GST tag) | Z500358

SIK is a protein kinase that is involved in regulating AMPK-related kinases . SIK may mediate the physiological effects of LKB1, including its tumour suppressor function. SIK is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane . This results in an increase in intracellular sodium in intact mammalian cells.

Functions:

The specific activity of SIK was determined to be 180 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

SNF1LK, MSK, SIK1

Gene Symbol:

SIK

Gene ID:

N/A

Accession:

NM_173354

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

61

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.