Recombinant Human SIK3 (N-GST tag) | Z500359

abm | Recombinant Human SIK3 (N-GST tag) | Z500359

SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm . Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer . There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer (3). SIK3 is a novel tumor-associated antigen (TAA).

Functions:

The specific activity of SIK3 was determined to be 140 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

QSK; SIK-3; L19; FLJ12240; KIAA0999

Gene Symbol:

SIK3

Gene ID:

N/A

Accession:

BC128510

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

62

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.