Recombinant Human SLK (N-GST tag) | Z500360

abm | Recombinant Human SLK (N-GST tag) | Z500360

SLK or LOSK is a Ste20-like protein kinase that associates with microtubule and centrosome. Inhibition of SLK activity by dominant-negative mutant or RNAi leads to unfocused microtubule arrangement indicating that SLK is needed for microtubule organization and for the proper localization of Golgi complex . Expression of v-Src can down-regulate SLK activity through the involvement of CK2 which can directly phosphorylate and inhibit SLK activity whereas inhibition of CK2 in v-Src-transformed cells results in normal SLK activity . CK2 and SLK can be co-localized in fibroblasts spreading on fibronectin-coated substrates.

Functions:

The specific activity of SLK was determined to be 4.6 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

LOSK, STK2, se20-9, KIAA0204, MGC133067, bA16H23.1

Gene Symbol:

SLK

Gene ID:

N/A

Accession:

AB002804

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

180

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.