Recombinant Human TAK1-TAB1 (N-GST tag) | Z500378

abm | Recombinant Human TAK1-TAB1 (N-GST tag) | Z500378

TAK1 is a serine/threonine protein kinase that mediates signaling by TGFß and morphogenetic protein (BMP) . In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (Nf?B). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8 . Thymocytes lacking TAK1 fail to activate Nf?B and JNK and are prone to apoptosis upon stimulation.

Functions:

The specific activity of TAK1-TAB1 was determined to be 10 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

TAK1: MAP3K7, TGF1a; TAB1: MAP3K7IP1, 3'-Tab1, MGC57664

Gene Symbol:

TAK1-TAB1

Gene ID:

N/A

Accession:

NM_003188, NM_006116

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

74

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.