Recombinant Human TRKA (N-GST tag) | Z500392

abm | Recombinant Human TRKA (N-GST tag) | Z500392

TRKA is a member of the trk proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation . A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease .

Functions:

The specific activity of TRKA was determined to be 22 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

NTRK1; MTC; TRK; TRK1; p140-TrkA; DKFZp781I14186

Gene Symbol:

TRKA

Gene ID:

N/A

Accession:

NM_002529

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

66

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.