Recombinant Human TTBK1 (N-GST tag) | Z500397

abm | Recombinant Human TTBK1 (N-GST tag) | Z500397

TTBK1 or tau-tubulin kinase 1 is a recently discovered brain-specific protein kinase involved in tau phosphorylation at Alzheimer’s disease-related sites. Two single nucleotide polymorphisms have been observed in the TTBK1 gene and these may play an important role in the pathogenesis of sporadic late-onset Alzheimer's disease . TTBK1 levels are upregulated in brains of human Alzheimer' disease (AD) patients compared with age-matched non-AD controls . Overexpression of TTBK1 in transgenic mice leads to increased phosphorylation-related neurofilament aggregation which results in significant age-dependent memory impairment.

Functions:

The specific activity of TTBK1 was determined to be 160 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

BDTK; RP3-330M21.4

Gene Symbol:

TTBK1

Gene ID:

N/A

Accession:

NM_032538

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

96

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.