Recombinant Human WNK2 (N-GST tag) | Z500408

abm | Recombinant Human WNK2 (N-GST tag) | Z500408

WNK2 is a serine/threonine kinase of the WNK (with no lysine (K)) protein kinase subfamily that also include WNK1, 3 and 4. The WNK kinases feature a cysteine residue in place of a lysine residue conserved in subdomain II of most kinases. WNK2 is predominantly expressed in brain, heart muscle, small intestine, and colon. As a tumor suppressor, WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway. WNK2 expression was found down-regulated epigenetically by promoter methylation in human gliomas.

Functions:

The specific activity of WNK2 was determined to be 2.0 nmol/min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

KIAA1760; NY-CO-43; P/OKcl.13; PRKWNK2; SDCCAG43

Gene Symbol:

WNK2

Gene ID:

N/A

Accession:

NM_006648

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

100

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.