SP100 Stable Knockout HEp-2 Cell Line | T6135

abm | SP100 Stable Knockout HEp-2 Cell Line | T6135

Nuclear domain 10 (ND10) bodies are membrane-less cellular components found in the nucleus that affect transcription and are implicated in some immune functions. ND10 bodies are able to detect and respond to viruses that infect cells, although many viruses have evolved to degrade or evade these ND 10 bodies. HSV-1 virus has the ability to degrade both the SP100 and PML ND10 bodies. Other viruses even have the ability to repurpose ND10 bodies to use in their replication. The SP100 Stable Knockout HEp-2 Cell Line has been previously used in research to better understand the role of ND10 bodies, SP100, host defences against viral infection. The cell line is ideal for virology research and studies pertaining to innate immune defences at the cellular level.

Biosafety:

II

Organism:

Human (H. sapiens)

Source Organ:

Other

Growth Properties:

Adherent

Morphology:

Epithelial

Clones:

N/A

Passage Number:

N/A

Population Doner:

N/A

Seeding Density:

N/A

Markers:

N/A

Applications:

For Research Use Only

Doner Gender:

N/A

Donor Ethnicity:

N/A

Knockdown Method:

N/A

Induction:

N/A

Overexpression:

N/A

Freeze Thaw:

N/A

Propagation:

The base medium for this cell line is Prigrow III medium available at abm

Preservation:

1. Freeze Medium: Complete growth medium with 20% FBS and 10% DMSO.
2. Storage Temperature: Liquid nitrogen vapour phase.

Quality Control:

N/A

Tumorgenicn:

N/A

Shipping Conditions:

Dry Ice

Storage Contidions:

-180°C