TrkA Stable T17 Cell Line | T3158

abm | TrkA Stable T17 Cell Line | T3158

TrkA Stable T17 Cell Line expresses rat TrkA (Tropomyosin receptor kinase A) after TrkA plasmid was successfully transfected into SN56 cells and were selected in the presence of G418. TrkA is the receptor for neurotrophins, such as nerve growth factor (NGF), which plays essential role in the nervous system – in particular apoptotic cell death prevention, and/or the promotion of cellular differentiation and axon elongation in neurons. Researchers may use the TrkA Stable T17 Cell Line to screen for NGF-like compounds that would act as TrkA agonists to study the mechanisms of the signaling pathways and affects NGF. The lack of TrkA has been associated with the neurodegenerative processes and thus the cell line is a valuable tool to conduct related studies.

Biosafety:

II

Organism:

Mouse

Source Organ:

Brain

Growth Properties:

Adherent

Morphology:

Polygonal

Clones:

N/A

Passage Number:

N/A

Population Doner:

N/A

Seeding Density:

Thaw entire contents into an appropriate T25 flask as specified in the Propagation instructions.

Markers:

N/A

Applications:

For Research Use Only

Doner Gender:

N/A

Donor Ethnicity:

N/A

Knockdown Method:

N/A

Induction:

N/A

Overexpression:

Rat TrkA receptor via transfection and G418 antibiotic selection

Freeze Thaw:

N/A

Propagation:

The base medium for this cell line is Prigrow III medium available at abm

Preservation:

N/A

Quality Control:

Selection with 300 mg/ml G418

Tumorgenicn:

N/A

Shipping Conditions:

Dry Ice

Storage Contidions:

-180°C