Recombinant Human BUB1B (N-GST tag) | Z500045

abm | Recombinant Human BUB1B (N-GST tag) | Z500045

BUB1B or budding uninhibited by benzimidazoles 1 homolog beta is involved in spindle checkpoint function and has been localized to the kinetochore. BUB1B plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation . BUB1B links the regulation of chromosome-spindle attachment to mitotic checkpoint signaling . BUB1B expression during the spindle checkpoint is dependent on residual BUB1B expression and impaired spindle checkpoint function has been found in many forms of cancer. BUB1B is essential for early embryonic development and normal hematopoiesis.

Functions:

The specific activity of BUB1B was determined to be 1.5 nmol /min/mg as per activity assay protocol

Organism:

Human

Source:

Insect cells

Alias:

SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1beta

Gene Symbol:

BUB1B

Gene ID:

N/A

Accession:

NM_001211

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

73

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.