Recombinant Human MEKK3 (N-GST tag) | Z500220

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SKU:
Z500220
Availability:
5 to 7 Days Shipment
€950.00
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Description

abm | Recombinant Human MEKK3 (N-GST tag) | Z500220

MEKK3 is a member of the MEKK family of protein kinases that directly regulate SAPK and ERK pathway but not the p38 pathway. MEKK3 modulates SAPK and ERK activity by activating the upstream targets SEK and MEK1/2, respectively . KSR2 can regulate the activity of MEKK3 and can reduce MEKK3-mediated ERK activation. Knockout of the MEKK3 gene in mice leads to disruption of blood vessel development and the structural integrity of the yolk sac . The blockage of angiogenesis in these mice is not a result of decreased VEGF1 expression but rather due to an intrinsic defect in Mekk3 -/- endothelial cells. Thus, MEKK3 is necessary for blood vessel development and may be a possible target for drugs that control angiogenesis.

Functions:

The specific activity of MEKK3 was determined to be 20 nmol /min/mg as per activity assay protocol

Organism:

Human

Source:

Insect cells

Alias:

MAP3K3, MAPKKK3

Gene Symbol:

MEKK3

Gene ID:

N/A

Accession:

NM_002401

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

105

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

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Additional Information

Size:
10 µg
Quantity:
Inquire
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