Recombinant Human PDHK4 (N-GST tag) | Z500282

abm | Recombinant Human PDHK4 (N-GST tag) | Z500282

PDHK4 or Pyruvate Dehydrogenase Kinase 4 is a member of the PDHK family that phosphorylate and inactivate the Pyruvate Dehydrogenase (PDH) . PDH is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDHK4 upregulation in adipocytes participates in the hypolipidemic effect of thiazolidinediones through modulation of glyceroneogenesis . PDHK4 expression is strongly and selectively induced by Rosiglitazone in a direct and transcriptional manner.

Functions:

The specific activity of PDHK4 was determined to be20 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PDK4; FLJ40832

Gene Symbol:

PDHK4

Gene ID:

N/A

Accession:

NM_002612

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

71

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.